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管清美

来源:   作者:   发布日期:2021-01-11     浏览次数:

     

一、基本信息

管清美 二级教授,博士。2002年毕业于西北农林科技大学果树专业,获农学学士学位;2005年毕业于西北农林科技大学果树专业,获硕士学位;2013年毕业于美国马里兰大学植物学专业,获博士学位。2005年-2008年在蚌埠学院任助教、讲师;2013-2014年在美国马里兰大学进行博士后研究工作;2014年到加拿大28预测开奖官网咪牌工作。国家青年人才项目、陕西省人才计划入选者,任新疆苹果产业技术体系副首席科学家、千阳苹果试验站首席科学家;主持国家自然科学基金杰出青年科学基金项目、优秀青年科学基金项目、国家重点研发计划等项目;荣获全国巾帼建功标兵、神农青年英才、陕西省青年科技新星等荣誉称号;获中国农学会青年科技奖、陕西省高等学校科学技术研究优秀成果奖等;兼任教育部科技委委员,教育部高等学校教指委委员。

二、研究方向

苹果耐非生物逆境(干旱、低温)的分子机制;苹果基因组学;苹果基因组设计育种。

三、科研项目

苹果抗逆分子机制与分子育种,国家自然科学基金杰出青年科学基金(2023-2028)

MdHDG5在苹果叶片蜡质合成及抗旱中的功能和机制解析,国家自然科学基金面上项目(2022-2026)

苹果现代育种技术研发与特色新种质创制,陕西省重点研发计划(2020-2024)

新疆苹果产业技术体系(生物育种技术),(2024-2029)

苹果GABA合成关键基因挖掘及作用机制研究,深圳市科学技术研究计划(2022-2025)

苹果成熟期调控关键基因挖掘及分子标记开发,深圳市科学技术研究计划(2021-2024)

旱地果园“膜水肥一体化”肥水高效利用技术研究与示范,国家重点研发计划(2022-2025)

果树优质丰产的生理基础与调控,国家重点研发计划(2018-2022)

多年生园艺作物无性系变异和繁殖的基础与调控,国家重点研发计划(2018-2022)

苹果MdARF-MdHYL1-MdMYB88/MdMYB124-MdSNF2调控网络解析及抗寒功能鉴定,国家自然科学基金面上项目(2019-2022)

苹果逆境分子生物学,国家自然科学基金优秀青年科学基金(2017-2019)

苹果耐旱的分子机制研究,国家青年人才计划项目(2016-2018)

苹果蛋白质降解相关蛋白在干旱胁迫中的作用,西北农林科技大学优青培育专项(2015-2017)

秦冠苹果一个锌指蛋白(MdZFP1)在干旱胁迫下的功能分析,国家自然科学基金面上项目(2016-2019)

苹果砧木耐旱关键小RNA的鉴定与分析,陕西省青年科技新星项目(2015-2017)

苹果矮化自根砧抗逆的分子机理及抗性改良, 西北农林科技大学引进人才科研启动项目(2014-2019)

四、主要学术论著

1.Song Y#, He J#, Guo J#, Xie Y, Ma Z, Liu Z, Niu C, Li X, Chu B, Tahir MM, Xu J, Ma F, Guan Q*. The chromatin remodeller MdRAD5B enhances drought tolerance by coupling MdLHP1-mediated H3K27me3 in apple. Plant Biotechnol J. 2024 Mar;22(3):617-634.

2.Xu J#, He J#,*, Hu B, Hou N, Guo J, Wang C, Li X, Li Z, Zhai J, Zhang T, Ma C, Ma F, Guan Q*. Global hypermethylation of the N6-methyladenosine RNA modification associated with apple heterografting. Plant Physiol. 2023 Nov 22;193(4):2513-2537.

3.Li X#, Ma Z, Song Y, Shen W, Yue Q, Khan A, Tahir MM, Wang X, Malnoy M, Ma F, Bus V, Zhou S*, Guan Q*. Insights into the molecular mechanisms underlying responses of apple trees to abiotic stresses. Hortic Res. 2023 Jul 27;10(8):uhad144.

4.Zhang D#, He J#, Cheng P, Zhang Y, Khan A, Wang S, Li Z, Zhao S, Zhan X, Ma F, Li X, Guan Q*. 4-methylumbelliferone (4-MU) enhances drought tolerance of apple by regulating rhizosphere microbial diversity and root architecture. Hortic Res. 2023 May 19;10(6):uhad099.

5.坎智勇, 张德辉*, 李中兴, 余思思, 钱谦, 樊天乐, 李雪薇, 马锋旺, 管清美*. 90个苹果品种耐寒性评价和全基因组关联分析[J]. 园艺学报, 2023, 50 (05): 921-932.

6.Shen X#, Song Y#, Ping Y, He J, Xie Y, Ma F, Li X, Guan Q*. The RNA-binding protein MdHYL1 modulates cold tolerance and disease resistance in apple. Plant Physiol. 2023 Jul 3;192(3):2143-2160.

7.Shen X#, Ping Y, Bao C, Liu C, Tahir MM, Li X, Song Y, Xu W, Ma F, Guan Q#,*. Mdm-miR160-MdARF17-MdWRKY33 module mediates freezing tolerance in apple. Plant J. 2023 Apr;114(2):262-278.

8.He, J#; Guo, J#; Jiang, L; An, W; Ma, F; Guan, Q*; Niu, C*. Transcriptional Effects of Rootstock on Scion after Drought: A Case Study of Using MdGH3 RNAi as the Rootstock.  Horticulturae  2022,  8 , 1212.

9.Cheng P#, Yue Q, Zhang Y, Zhao S, Khan A, Yang X, He J, Wang S, Shen W, Qian Q, Du W, Ma F, Zhang D*, Guan Q*. Application of γ-aminobutyric acid (GABA) improves fruit quality and rootstock drought tolerance in apple. J Plant Physiol. 2023 Jan;280:153890.

10.Bao C#, Qin G, Cao F, He J, Shen X, Chen P, Niu C, Zhang D, Ren T, Zhi F, Ma L, Ma F, Guan Q*. MdZAT5 regulates drought tolerance via mediating accumulation of drought-responsive miRNAs and mRNAs in apple. New Phytol. 2022 Dec;236(6):2131-2150.

11.Niu C#, Jiang L#, Cao F#, Liu C, Guo J, Zhang Z, Yue Q, Hou N, Liu Z, Li X, Tahir MM, He J, Li Z, Li C, Ma F, Guan Q*. Methylation of a MITE insertion in the MdRFNR1-1 promoter is positively associated with its allelic expression in apple in response to drought stress. Plant Cell. 2022 Sep 27;34(10):3983-4006.

12.储宝华, 曹富国, 卞宁宁, 钱谦, 李中兴, 李雪薇, 刘泽远, 马锋旺, 管清美*. 84个苹果栽培品种对斑点落叶病的抗性评价和全基因组关联分析[J]. 中国农业科学, 2022, 55 (18): 3613-3628.

13.Chen P#., Zhi F#., Li X.#, Shen W., Yan M., He J., Bao C., Fan T., Zhou S., Ma F., & Guan Q*. Zinc-finger protein MdBBX7/MdCOL9, a target of MdMIEL1 E3 ligase, confers drought tolerance in apple. Plant physiology, 2022 188(1), 540–559.

14.Li Z#, Wang L#, He J#, Li X#, Hou N, Guo J, Niu C, Li C, Liu S, Xu J, Xie Y, Zhang D, Shen X, Lu L, Geng D, Chen P, Jiang L, Wang L, Li H, Malnoy M, Deng C, Zou Y, Li C, Zhan X, Dong Y, Notaguchi M, Ma F*, Xu Q*, Guan Q*. Chromosome-scale reference genome provides insights into the genetic origin and grafting-mediated stress tolerance of Malus prunifolia. Plant Biotechnol J. 2022 Jun;20(6):1015-1017.

15.Li X#, Zhou S, Liu Z, Lu L, Dang H, Li H, Chu B, Chen P, Ma Z, Zhao S, Li Z, van Nocker S, Ma F*, Guan Q*. Fine-tuning of SUMOylation modulates drought tolerance of apple. Plant Biotechnol J. 2022 May;20(5):903-919.

16.Hou N#, Li C#, He J, Liu Y, Yu S, Malnoy M, Mobeen Tahir M, Xu L, Ma F, Guan Q*. MdMTA-mediated m6 A modification enhances drought tolerance by promoting mRNA stability and translation efficiency of genes involved in lignin deposition and oxidative stress. New Phytol. 2022 May;234(4):1294-1314.

17.赵爽, 马子清, 张雨田, 程鹏达, 李文强, 管清美*. 陕西渭北地区不同时期控水对苹果产量、品质和水分利用效率的影响[J]. 北方园艺, 2022, (21): 38-43.

18.Hou N#, Li C#, He J, Liu Y, Yu S, Malnoy M, Mobeen Tahir M, Xu L, Ma F, Guan Q*. MdMTA-mediated m6 A modification enhances drought tolerance by promoting mRNA stability and translation efficiency of genes involved in lignin deposition and oxidative stress. New Phytol. 2022 May;234(4):1294-1314.

19.Jiang L#, Zhang D, Liu C, Shen W, He J, Yue Q, Niu C, Yang F, Li X, Shen X, Hou N, Chen P, Ma F, Guan Q*. MdGH3.6 is targeted by MdMYB94 and plays a negative role in apple water-deficit stress tolerance. Plant J. 2022 Mar;109(5):1271-1289.

20.GENG Da-li#, LI Lei, YANG Yu-sen, MA Feng-wang, GUAN Qing-mei*. Factors affecting hydraulic conductivity and methods to measure in plants,Journal of Integrative Agriculture,Volume 21, Issue 2,2022,Pages 310-315,ISSN 2095-3119.

21.Chen P#, Zhi F#, Li X#, Shen W, Yan M, He J, Bao C, Fan T, Zhou S, Ma F, Guan Q*. Zinc-finger protein MdBBX7/MdCOL9, a target of MdMIEL1 E3 ligase, confers drought tolerance in apple. Plant Physiol. 2022 Jan 20;188(1):540-559.

22.Jiang L#, Shen W#, Liu C, Tahir MM, Li X, Zhou S, Ma F, Guan Q*. Engineering drought-tolerant apple by knocking down six GH3 genes and potential application of transgenic apple as a rootstock. Hortic Res. 2022 May 26;9:uhac122.

23.Cao F#, Li Z#, Jiang L#, Liu C, Qian Q, Yang F, Ma F, Guan Q*. Genome-wide association study (GWAS) of leaf wax components of apple. Stress Biol. 2021 Nov 18;1(1):13.

24.Chen P#, Li Z#, Zhang D#, Shen W#, Xie Y, Zhang J, Jiang L, Li X, Shen X, Geng D, Wang L, Niu C, Bao C, Yan M, Li H, Li C, Yan Y, Zou Y, Micheletti D, Koot E, Ma F*, Guan Q*. Insights into the effect of human civilization on Malus evolution and domestication. Plant Biotechnol J. 2021 Nov;19(11):2206-2220.

25.Li C#, Hou N#, Fang N, He J, Ma Z, Ma F, Guan Q*, Li X*. Cold shock protein 3 plays a negative role in apple drought tolerance by regulating oxidative stress response. Plant Physiol Biochem. 2021 Nov;168:83-92.

26.Liu X#, Zhao C#, Gao Y, Xu Y, Wang S, Li C, Xie Y, Chen P, Yang P, Yuan L, Wang X, Huang L, Ma F, Feng H, Guan Q*. A multifaceted module of BRI1 ETHYLMETHANE SULFONATE SUPRESSOR1 (BES1)-MYB88 in growth and stress tolerance of apple. Plant Physiol. 2021 Apr 23;185(4):1903-1923.

27.Zhang D#, Yang K#, Kan Z, Dang H, Feng S, Yang Y, Li L, Hou N, Xu L, Wang X, Malnoy M, Ma F, Hao Y, Guan Q*. The regulatory module MdBT2-MdMYB88/MdMYB124-MdNRTs regulates nitrogen usage in apple. Plant Physiol. 2021 Apr 23;185(4):1924-1942.

28.Xie Y#, Bao C, Chen P, Cao F, Liu X, Geng D, Li Z, Li X, Hou N, Zhi F, Niu C, Zhou S, Zhan X, Ma F, Guan Q*. Abscisic acid homeostasis is mediated by feedback regulation of MdMYB88 and MdMYB124. J Exp Bot. 2021 Feb 2;72(2):592-607.

29.Baohua CHU#, Jia SUN#, Huan DANG, Ziqing MA, Shuang ZHAO, Qingmei GUAN*, Xuewei LI*.APPLE SUMO E3 LIGASE MDSIZ1 NEGATIVELY REGULATES DROUGHT TOLERANCE[J].Frontiers of Agricultural Science and Engineering,2021,(prepublish):0-.

30.Zhao C#, Liu X#, He J, Xie Y, Xu Y, Ma F, Guan Q*. Apple TIME FOR COFFEE contributes to freezing tolerance by promoting unsaturation of fatty acids. Plant Sci. 2021 Jan;302:110695. doi: 10.1016/j.plantsci.2020.110695.

31.Chen P#, Yan M, Li L, He J, Zhou S, Li Z, Niu C, Bao C, Zhi F, Ma F, Guan Q*. The apple DNA-binding one zinc-finger protein MdDof54 promotes drought resistance. Hortic Res. 2020 Dec 1;7(1):195.

32.Geng D#, Shen X#, Xie Y, Yang Y, Bian R, Gao Y, Li P, Sun L, Feng H, Ma F, Guan Q*. Regulation of phenylpropanoid biosynthesis by MdMYB88 and MdMYB124 contributes to pathogen and drought resistance in apple. Hortic Res. 2020 Jul 1;7:102.

33.Li X#, Chen P#, Xie Y, Yan Y, Wang L, Dang H, Zhang J, Xu L, Ma F, Guan Q*. Apple SERRATE negatively mediates drought resistance by regulating MdMYB88 and MdMYB124 and microRNA biogenesis. Hortic Res. 2020 Jul 1;7(1):98. doi: 10.1038/s41438-020-0320-6.

34.杨锋, 刘晨, 姜丽娟, 管清美*. 苹果属植物抗旱性评价[J]. 西北农林科技大学学报(自然科学版), 2020, 48 (08): 119-128.

35.Li, Xuewei#; Xie, Yinpeng#; Lu, Liyuan; Yan, Mingjia; Fang, Nan; Xu, Jidi; Wang, Liping; Yan, Yan; Zhao, Tao; van Nocker, Steve; Ma, Fengwang; Liang, Dong; Guan*, Qingmei*. Contribution of methylation regulation of MpDREB2A promoter to drought resistance of Mauls prunifolia[J].Plant and Soil,2019,441(1-2):15-32.

36.Geng Da-li#; Lu Li-yuan#; Yan Ming-jia; Shen Xiao-xia; Jiang Li-juan; Li Hai-yan; Wang Li-ping; Yan Yan; Xu Ji-di; Li Cui-ying; Yu Jian-tao; Ma Feng-wang; Guan Qing-mei*. Physiological and transcriptomic analyses of roots from Malus sieversii under drought stress[J].Journal of Integrative Agriculture, 2019, v.18(06):108-122.

37.Niu C#, Li H#, Jiang L, Yan M, Li C, Geng D, Xie Y, Yan Y, Shen X, Chen P, Dong J, Ma F, Guan Q*. Genome-wide identification of drought-responsive microRNAs in two sets of Malus from interspecific hybrid progenies. Hortic Res. 2019 Jun 8;6:75.

38.Geng D#, Chen P#, Shen X, Zhang Y, Li X, Jiang L, Xie Y, Niu C, Zhang J, Huang X, Ma F, Guan Q*. MdMYB88 and MdMYB124 Enhance Drought Tolerance by Modulating Root Vessels and Cell Walls in Apple. Plant Physiol. 2018 Nov;178(3):1296-1309.

39.Xie Y#, Chen P#, Yan Y, Bao C, Li X, Wang L, Shen X, Li H, Liu X, Niu C, Zhu C, Fang N, Shao Y, Zhao T, Yu J, Zhu J, Xu L, van Nocker S, Ma F, Guan Q*. An atypical R2R3 MYB transcription factor increases cold hardiness by CBF-dependent and CBF-independent pathways in apple. New Phytol. 2018 Apr;218(1):201-218.

40.王丽平, 姜丽娟, 马锋旺, 管清美*. 苹果HYL1基因在干旱中的表达与功能分析[J]. 西北农林科技大学学报(自然科学版), 2018, 46 (07): 109-116.

41.Xu J#, Zhou S, Gong X, Song Y, van Nocker S, Ma F*, Guan Q*. Single-base methylome analysis reveals dynamic epigenomic differences associated with water deficit in apple. Plant Biotechnol J. 2018 Feb;16(2):672-687.

42.李海燕, 耿达立, 牛春东, 李翠英, 管清美*. 苹果砧木富平楸子和G935根系抗旱性评估[J]. 西北农林科技大学学报(自然科学版), 2018, 46 (05): 118-124.

43.赵爽, 马子清, 李雪薇, 李文强, 管清美*. 不同果实生长期亏缺灌溉对渭北苹果生长、品质及水分利用效率的影响[J]. 西北植物学报, 2024, 44 (03): 345-352.

44.3. 赵爽, 马子清, 李雪薇, 赵海亮, 管清美*. 不同时期水分胁迫对渭北苹果品质及水分利用效率的影响[J]. 西北园艺(果树), 2024, (02): 60-63.

五、获批专利

1. 管清美、程鹏达、张德辉、岳倩宇、赵爽、张雨田、杨欣玥、毛秀山。提高苹果矮化砧木水分利用率和果实品质氨基酸施用方法。状态:已授权。专利号:ZL 202210158183.4

2. 管清美、张德辉、程鹏达、张雨田、赵爽。4-甲基伞形酮在提高植物抗干旱上的用途。状态:已授权。专利号:ZL2022111466082.5。

3. 管清美、申小霞、毛秀山、平怡坤、李雪薇、樊天乐、张子桐。促进砧木根系发育及抗旱的可移动miRNA及鉴定方法。状态:已授权。专利号:ZL202120550698.4。

4. 管清美、牛春东、张子桐、曹富国、钱谦、刘泽远、李中兴、姜丽娟。一种应用于苹果转基因的药剂浓度筛选方法。状态:已授权。专利号:ZL202111250967.1